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dc.contributor.authorArruda, Sérgio Marcos-
dc.contributor.authorTakenami, I.-
dc.contributor.authorOliveira, C. C. de-
dc.contributor.authorPetrilli, J. D.-
dc.contributor.authorMachado Jr, A.-
dc.contributor.authorRiley, L. W.-
dc.date.accessioned2019-06-26T13:55:26Z-
dc.date.available2019-06-26T13:55:26Z-
dc.date.issued2018-
dc.identifier.issn1063–1070-
dc.identifier.numberVolume 22, n° 9pt_BR
dc.identifier.urihttp://www7.bahiana.edu.br//jspui/handle/bahiana/2970-
dc.description.abstractOBJECTIVE: To evaluate the immunoglobulin (Ig)M and total IgG antibody response to cardiolipin (CL), phosphatidylcholine (PTC), phosphatidylethanolamine (PE), phosphatidylinositol (PI) and sulfatide (SL-I) as biosignatures that can be used to diagnose pulmonary tuberculosis (TB) and its applicability for monitoring the efficacy of anti-tuberculosis treatment. DESIGN: Serum samples from 37 adult pulmonary TB patients and 48 controls (16 healthy household contacts, 19 household contacts with latent tuberculous infection [LTBI] and 13 non-TB patients with lung disease) were screened using enzyme-linked immunosorbent assays (ELISAs) for IgM and total IgG against phospholipids. RESULTS: Levels of IgM response to CL, PE and PI, and IgG response to CL, PE, PI and PTC were significantly higher in TB patients than in control groups. Anti-CL IgG had the best performance characteristics, with a sensitivity and specificity of respectively 86.5% and 87.2%. This IgG anti-CL ELISA test detected 86.5% (32/37) of the TB patients, whereas the number detected using sputum smear was only 65.9% (24/37). After antituberculosis treatment, the median value for all antiphospholipid antibodies decreased significantly compared with baseline values (P , 0.05). CONCLUSION: Our results suggest that the total IgG anti-CL level could be useful to complement conventional bacteriological tests for the rapid diagnosis of adult pulmonary TB.pt_BR
dc.language.isoenpt_BR
dc.sourcehttps://www.ingentaconnect.com/content/iuatld/ijtldpt_BR
dc.subjectCardiolipin; Phosphatidylcholine; Phosphatidylethanolamine; Phosphatidylinositol; Sulfatidept_BR
dc.titleSerum antiphospholipid antibody levels as biomarkers for diagnosis of pulmonary tuberculosis patientspt_BR
dc.title.alternativeInt J Tuberc Lung Dispt_BR
dc.typeProdução bibliográfica: Artigos completos publicados em periódicospt_BR
Aparece nas coleções:Artigos Completos Publicados em Periódicos

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