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dc.contributor.authorBastos, Maria de Lourdes Santana-
dc.contributor.authorSouza, Anselmo-
dc.contributor.authorCarvalho, Nathália-
dc.contributor.authorNeves, Yuri-
dc.contributor.authorSantos, Silvane Braga-
dc.contributor.authorArruda, Sérgio-
dc.contributor.authorMartins Netto, Eduardo-
dc.contributor.authorGlesby, Marshall J.-
dc.contributor.authorCarvalho, Edgar-
dc.date.accessioned2019-10-15T13:19:20Z-
dc.date.available2019-10-15T13:19:20Z-
dc.date.issued2017-11-01-
dc.identifier.numberVol. 33 Nº 11pt_BR
dc.identifier.urihttps://repositorio.bahiana.edu.br:8443/jspui/handle/bahiana/3467-
dc.description.abstractThe human T cell lymphotropic virus type 1 (HTLV-1) is the etiologic agent of HTLV-1- associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1 infected individuals have increased susceptibility to Mycobacterium tuberculosis infection but the influence of tuberculosis (TB) on the course of HTLV-1 infection is unknown. The aim of this study was to evaluate the influence of TB on immunological, virologic, and neurologic features of HTLV-1 infection. This is a retrospective analysis of individuals enrolled in a cohort study from an HTLV1 clinic who were evaluated for past or latent tuberculosis (LTB) and classified clinically as HTLV-1 carriers, probable HAM/TSP and definite HAM/TSP. Spontaneous cytokine production (interferon-gamma [IFN-γ], tumor necrosis factor [TNF], and interleukin[IL]-10), serum chemokines (CXCL9 and CXCL10) and HTLV-1 proviral load were evaluated. Of 172 participants, 64 did not have histories of TB (TB- group), 81 had LTB and 27 had TB in the past (TB+ group). In the TB+ group, there was a higher frequency of HAM/TSP patients (35%) than in HTLV-1 carriers (10%) (OR = 3.8, p = .0001). HAM/TSP patients with histories of TB had higher IFN-γ/IL-10 and TNF/IL-10 ratios when compared with HAM/TSP patients without histories of TB. There were no differences in serum chemokine production and proviral load across TB groups stratified on HTLV-1 clinical status. In conclusion, TB may influence the development of HAM/TSP, and patients with these two diseases have an impairment in the modulation of immune response.pt_BR
dc.language.isoenpt_BR
dc.sourcehttps://www.liebertpub.com/doi/10.1089/aid.2015.0340pt_BR
dc.subjectHTLV-1; Tuberculosis; Immune responsept_BR
dc.titleAssociation of Tuberculosis Status with Neurologic Disease and Immune Response in HTLV-1 Infectionpt_BR
dc.title.alternativeMary Ann Liebert, Inc Publisherpt_BR
dc.typeProdução bibliográfica: Artigos completos publicados em periódicospt_BR
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