Please use this identifier to cite or link to this item: https://repositorio.bahiana.edu.br:8443/jspui/handle/bahiana/3037
Title: Opioid peptides and gastrointestinal symptoms in autism spectrum disorders
Other Titles: Revista Brasileira de Psiquiatria
Authors: Rodrigues, Luiz Erlon Araujo
Lázaro, Cristiane P.
Rodrigues, Luiz E. A.
Keywords: Autistic disorder; Probability theory; Opioids; Intestinal bacteria; Oxidative stress; Bowel permeability
Issue Date: 24-Jan-2016
Abstract: Autism spectrum disorders (ASDs) are characterized by deficits in the individual’s ability to socialize, communicate, and use the imagination, in addition to stereotyped behaviors. These disorders have a heterogenous phenotype, both in relation to symptoms and regarding severity. Organic problems related to the gastrointestinal tract are often associated with ASD, including dysbiosis, inflammatory bowel disease, exocrine pancreatic insufficiency, celiac disease, indigestion, malabsorption, food intolerance, and food allergies, leading to vitamin deficiencies and malnutrition. In an attempt to explain the pathophysiology involved in autism, a theory founded on opioid excess has been the focus of various investigations, since it partially explains the symptomatology of the disorder. Another hypothesis has been put forward whereby the probable triggers of ASDs would be related to the presence of bacteria in the bowel, oxidative stress, and intestinal permeability. The present update reviews these hypotheses.
URI: http://www7.bahiana.edu.br//jspui/handle/bahiana/3037
ISSN: 1809-452X
Appears in Collections:Artigos Completos Publicados em Periódicos

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