Please use this identifier to cite or link to this item: https://repositorio.bahiana.edu.br:8443/jspui/handle/bahiana/3063
Title: Revisiting the Heterogeneous IFN-γ Response of Bacille of Calmette-Guérin (BCG)- Revaccinated Healthy Volunteers in a Randomized Controlled Trial: Effect of the Body Mass Index and of the IFNG+874 A/T Polymorphism
Other Titles: Revista Plos one
Authors: Marinho, Jamocyr Moura
Conceição, Elisabete L.
Sampaio, Francisco S.Nascimento
Schwingel, Paulo A.
Oliveira, Evelin S.
Rocha, Michael S.
Vieira, Igor
Mendes, Carlos M. C.
Machado, Adelmir Souza
Oliveira, Martha M.
Barral-Netto, Manoel
Barbosa, Theolis
Issue Date: 29-Jul-2016
Abstract: In trials evaluating the immune responses to Bacille of Calmette-Guérin (BCG), the genetic background and the nutritional status are host-related factors that could affect the heterogeneity in these parameters. The IFNG+874 A/T (rs 62559044) polymorphism has been reported to influence the IFN-γ production by BCG-vaccinated individuals challenged in vitro with mycobacterial antigens. The body mass index (BMI) is a proxy for the nutritional status and has been associated both with the susceptibility to tuberculosis and with the IFNγ response. We show that although the IFNG+874 A/T polymorphism was not associated with the heterogeneity of IFN-γ production in a randomized controlled trial that evaluated long-term immune responses to BCG revaccination previously conducted in Salvador, Bahia, Brazil, the effect of this polymorphism on the observed increase in IFN-γ production among revaccinated subjects was adjusted in individuals with a low BMI.
URI: http://www7.bahiana.edu.br//jspui/handle/bahiana/3063
Appears in Collections:Artigos Completos Publicados em Periódicos

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